The rise and migration of the Hephthalites left a significant impact on the exchange of East-West civilizations, and the empire they established was one of the inevitable problems in the study of Silk Road. The period from the end of 5th century to the early 6th century was the zenith of Hephthalite Empire when the alliance between Hephthalites and Sasanians was established and the Hephthalites expanded to Tarim Basin and southward to North-West India. The Hephthalite Empire played an important intermediary role in the interaction of East-West civilizations, ensuring the stable development of the Silk Road in the 5th and 6th centuries and laying the foundation for the prosperity of the Silk Road during the Sui and Tang Dynasties. The Chinese Northern and Southern Dynasties observed the Hephthalites in China and noted their interactions with different ethnic groups, such as the Han Chinese, Sogdians and Persians. Chinese written sources such as the Book of Wei, the Book of Zhou (Zhoushu 周书), the Book of Liang (Liangshu, 梁书), the History of Northern Dynasties (Beishi, 北史), the Book of Sui (Suishu, 隋书), the New Book of Tang (Xintangshu, 新唐书) as well as Comprehensive Statutes (Tongdian, 通典), provide substantial information about the Hephthalites. With the advancement of archaeological discoveries in recent years, the Hephthalite coins and Persian coins have also become crucial numismatic evidence for understanding the Hephthalite activities in medieval China and their relations with different ethnic groups in China and along the Silk Road.