The vast expanse of the Persepolis World Heritage site and its three buffer zones, along with the numerous historical remains within these boundaries—including hills, sites, and various historical mines—have presented significant challenges for the registration, documentation, monitoring, and ongoing care of these cultural assets, despite enhancing the region’s historical and cultural capacities. Although the registration and documentation of the artifacts in this area have long been a focus of the Persepolis World Heritage Site, the sheer number of artifacts has highlighted the need for more advanced documentation tools and methods. Drone-based documentation was one of the selected approaches to expand documentation activities in this area, and a three-day conference and workshop were held to discuss related topics. The most important topics discussed at the conference included: the necessity of documentation, the role of documentation in global registration processes, flight regulations and legal aspects of drone-based documentation, and case studies of using drones for studying and documenting cultural heritage. These topics were presented by 20 speakers during the scientific program of the conference. At the conclusion of the conference and workshop, a six-point declaration was prepared, with the text drafted and signed by representatives of the institutions present. This declaration emphasized the need to pay greater attention to documentation as a tool for research, understanding cultural and natural heritage, optimal presentation, and preservation.